Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules†,10.1039/C8OB01754A

批量搜索

批量搜索

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules†

Tapan Kumar Kuilya,Subhendu Das,Dhiman Saha,Rajib Kumar Goswami

Organic & Biomolecular Chemistry Pub Date : 08/23/2018 00:00:00 , DOI:10.1039/C8OB01754A

Abstract

Stereoselective synthesis of common C₁–C₁₉ skeletons of pentane macrolides strevertenes A and G possessing 10 stereogenic centers has been achieved using a flexible and convergent strategy. The salient features of this synthetic study include the Evans aldol reaction for the constructions of C₂, C₃, C₁₃, and C₁₄ centers, CBS reduction for the generation of a C₇ center, Hoveyda–Grubbs cross olefin metathesis for the synthesis of C₈–C₉ bond, and Wittig olefination for the installation of C₁₆–C₁₉ conjugated olefins.