Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89†,10.1039/C8OB01434E

批量搜索

批量搜索

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89†

F. Gao,C. Ieritano,K.-T. Chen,G. M. Dias,J. Rousseau,Y. Seimbille

Organic & Biomolecular Chemistry Pub Date : 07/02/2018 00:00:00 , DOI:10.1039/C8OB01434E

Abstract

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.