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Synthesis of sulfonamides via I2-mediated reaction of sodium sulfinates with amines in an aqueous medium at room temperature†
Xiaojun Pan,Jian Gao,Juan Liu,Junyi Lai,Huanfeng Jiang,Gaoqing Yuan
Green Chemistry Pub Date : 12/22/2014 00:00:00 , DOI:10.1039/C4GC02115K
Abstract

An efficient I2-mediated approach for the synthesis of sulfonamides at room temperature using water as the solvent has been developed. This method for the synthesis of sulfonamides is quite convenient and environmentally friendly. In addition, the purification procedure of the desired products becomes very easy.

Graphical abstract: Synthesis of sulfonamides via I2-mediated reaction of sodium sulfinates with amines in an aqueous medium at room temperature
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