Synthesis and antiproliferative activity of N-glycosyl-3,3-diaryloxindoles†,10.1039/C4RA02627F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis and antiproliferative activity of N-glycosyl-3,3-diaryloxindoles†

Dennis Kleeblatt,Christoph A. Cordes,Philipp Lebrenz,Martin Hein,Holger Feist,Abdul Matin,Rabia Raza,Jamshed Iqbal,Qamar Rahman,Alexander Villinger

RSC Advances Pub Date : 05/02/2014 00:00:00 , DOI:10.1039/C4RA02627F

Abstract

N-Glycosylated 3,3-diaryloxindoles were prepared by Lewis acid catalyzed reaction of acetylated N-glycosylisatins with various benzene derivatives and subsequent deprotection. Some of the products showed antiproliferative activity against malignant cutaneous melanoma cells HT-144 (ATCC HTB-63) and lung carcinoma (H157) cell lines (ATCC CRL-5802).