Copper ferrite (CuFe₂O₄) magnetic hollow fibers were prepared by applying an organic sol-thermal decomposition method, and silver nanoparticles were subsequently loaded on the fibers by calcination. The Ag–CuFe₂O₄ fibers exhibited excellent antibacterial efficacy against four different bacteria (E. coli, S. typhi, S. aureus and V. parahaemolyticus) with consistent results. Typical ferromagnetism behavior exhibited from the Ag–CuFe₂O₄ fibers enables their feasible recyclability.