Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses†,10.1039/C8CC03907K

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses†

Tadahiro Shimazu,Joaquin Barjau,Shinya Fujishiro,Mai Akakabe,Yoichi Shinkai

Chemical Communications Pub Date : 07/31/2018 00:00:00 , DOI:10.1039/C8CC03907K

Abstract

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.