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Urea-catalyzed construction of oxazinanes†
Andrea M. Hardman,Sonia S. So,Anita E. Mattson
Organic & Biomolecular Chemistry Pub Date : 07/29/2013 00:00:00 , DOI:10.1039/C3OB41517A
Abstract

Highly functionalized oxazinanes are efficiently prepared through urea-catalyzed formal [3 + 3] cycloaddition reactions of nitrones and nitrocyclopropane carboxylates. The reaction system is general with respect to both the nitrocyclopropane carboxylates and nitrones enabling the preparation of a large family of oxazinanes, typically in high yield. This method affords access to enantioenriched oxazinane products through chirality transfer from enantioenriched nitrocyclopropane carboxylates.

Graphical abstract: Urea-catalyzed construction of oxazinanes
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