The electrocatalytic efficiency of metal nanoparticles depends on their structures as well as compositions. The analytical performance of four Ag-based metal (Ag, AgPt, AgAu, and AgAuPt) nanostructure modified electrodes for detection of hydrogen peroxide was investigated. Silver nanoparticles (Ag NPs) were deposited on an indium tin oxide (ITO) film coated glass surface. Then Ag NPs were used as sacrificed template to generate AgPt, AgAu, and AgAuPt hybrid hollow nanostructures using a galvanic replacement reaction. The AgAuPt nanocages (AgAuPt NCs) show the highest sensitivity for electrochemical detection of hydrogen peroxide in all the metal nanostructures. This modified electrode exhibits a linear current response to hydrogen peroxide concentration in the range of 4 μM to 4 mM with a detection limit of 2 μM at an applied potential of −0.35 V. These results indicate that AgAuPt NCs could be a promising electrochemical material for detection of hydrogen peroxide.