960化工网
Visible-light-induced photocatalyst-free C-3 functionalization of indoles with diethyl bromomalonate†
Guangmiao Gu,Mengmeng Huang,Jung Keun Kim,Jianye Zhang,Yabo Li,Yangjie Wu
Green Chemistry Pub Date : 03/19/2020 00:00:00 , DOI:10.1039/D0GC00292E
Abstract

A visible-light induced green and efficient method is developed for the synthesis of α-indolyl diethyl malonates. The reaction proceeds without any photocatalysts or ligands in a green solvent in a short time. Moreover, the reaction mechanism has been clearly studied by control experiments, spectrophotometric studies and density functional theory (DFT) calculations. The results showed that the photocatalyst-free transformation may proceed via an XB-promoted radical process. The EDA complex formation of diethyl bromomalonate with a base is the main reason for the reaction initiation.

Graphical abstract: Visible-light-induced photocatalyst-free C-3 functionalization of indoles with diethyl bromomalonate
平台客服
平台客服
平台在线客服