Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes†,10.1039/C8OB01882K

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Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes†

Ailada Charoenpol,Jatuporn Meesin,Onnicha Khaikate,Vichai Reutrakul,Manat Pohmakotr,Pawaret Leowanawat,Darunee Soorukram,Chutima Kuhakarn

Organic & Biomolecular Chemistry Pub Date : 09/14/2018 00:00:00 , DOI:10.1039/C8OB01882K

Abstract

A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(I) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in moderate to good yields.