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Synthesis of an enantiopure scorpionate ligand by a nucleophilic addition to a ketenimine and a zinc initiator for the isoselective ROP of rac-lactide†
Manuel Honrado,Sonia Sobrino,Juan Fernández-Baeza,Luis F. Sánchez-Barba,Andrés Garcés,Agustín Lara-Sánchez,Ana M. Rodríguez
Chemical Communications Pub Date : 07/02/2019 00:00:00 , DOI:10.1039/C9CC04716F
Abstract

A novel nucleophilic addition of an organolithium to a ketenimine to prepare an enantiopure NNN-heteroscorpionate ligand is described. We verified its potential utility as a valuable scaffold for chirality induction through the preparation of enantiopure zinc complexes, which behave as highly efficient initiators to produce highly-enriched isotactic poly(lactide)s (Pi up to 0.88).

Graphical abstract: Synthesis of an enantiopure scorpionate ligand by a nucleophilic addition to a ketenimine and a zinc initiator for the isoselective ROP of rac-lactide
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