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Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions†
Yasushi Satoh,Yasushi Obora
RSC Advances Pub Date : 03/21/2014 00:00:00 , DOI:10.1039/C4RA01153H
Abstract

We developed a simple strategy for the synthesis of arylacetonitriles from benzyl chlorides and trimethylsilyl cyanide using a Ni(cod)2/PPh3 catalyst.

Graphical abstract: Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions
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