Synthesis and anti-mycobacterial activity of glycosyl sulfamides of arabinofuranose†
Kajitha Suthagar
Organic & Biomolecular Chemistry Pub Date : 01/05/2016 00:00:00 , DOI:10.1039/C5OB02317C
Abstract

A series of arabino N-glycosyl sulfamides, forced to adopt the furanose form by removal of the 5-hydroxyl group, were synthesised as putative isosteric mimics of decaprenolphosphoarabinose, the donor processed by arabinosyltransferases during mycobacterial cell wall assembly. Compounds showed moderate anti-mycobacterial activity, which was maximal for a C10 sulfamide side chain.

Graphical abstract: Synthesis and anti-mycobacterial activity of glycosyl sulfamides of arabinofuranose