Synthesis of functionalized Morita–Baylis–Hillman adducts by a conjugate addition–elimination sequence†
Rémi Aouzal,Joëlle Prunet
Organic & Biomolecular Chemistry Pub Date : 07/10/2009 00:00:00 , DOI:10.1039/B907373F
Abstract

We have developed a new conjugate addition–elimination sequence for the diastereoselective synthesis of protected allylic syn 1,3-diols which are Morita–Baylis–Hillman adducts. The synthesis of the substrates involves a challenging cross-metathesis reaction that leads to hindered trisubstituted olefins.

Graphical abstract: Synthesis of functionalized Morita–Baylis–Hillman adducts by a conjugate addition–elimination sequence