Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists†
Michael P. Van Ryssen,Nicolaos Avlonitis,Rashid Giniatullin,Craig McDougall,James L. Carr,Emma L. A. Borgström,C. Tom A. Brown,Dmitriy Fayuk,Alexander Surin,Minna Niittykoski,Leonard Khiroug,Stuart J. Conway
Organic & Biomolecular Chemistry Pub Date : 09/24/2009 00:00:00 , DOI:
10.1039/B914981CAbstract
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
