Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents
Nectaroula Cooper,David R. Hagan,Arnaud Tiberghien,Temitope Ademefun,Charles S. Matthews,Philip W. Howard,David E. Thurston
Chemical Communications Pub Date : 07/15/2002 00:00:00 , DOI:10.1039/B205136B
Abstract
Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.
