Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and a copper mediated tandem cyanation–lactonization approach†,10.1039/C4OB00965G

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and a copper mediated tandem cyanation–lactonization approach†

U. Nookaraju,Eeshwaraiah Begari,Pradeep Kumar

Organic & Biomolecular Chemistry Pub Date : 05/29/2014 00:00:00 , DOI:10.1039/C4OB00965G

Abstract

A simple and novel synthesis of (+)-monocerin was achieved in 15 steps and 15.5% overall yield from 3-buten-1-ol employing hydrolytic kinetic resolution, Julia olefination, intramolecular tandem Sharpless asymmetric dihydroxylation-S_N2 cyclization and a novel copper mediated tandem cyanation–cyclization as the key steps.