Total synthesis of (+)-petromyroxol via tandem α-aminoxylation–allylation and asymmetric dihydroxylation–SN2 cyclization approach†‡,10.1039/C5RA10405J

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Total synthesis of (+)-petromyroxol via tandem α-aminoxylation–allylation and asymmetric dihydroxylation–SN2 cyclization approach†‡

U. Nookaraju,Pradeep Kumar

RSC Advances Pub Date : 07/17/2015 00:00:00 , DOI:10.1039/C5RA10405J

Abstract

The total synthesis of (+)-petromyroxol, a tetrahydrofuran (THF)-diol fatty acid, isolated from sea lamprey larvae (Petromyzon marinus) is reported. The present synthesis employs a tandem α-aminoxylationallylation, cross metathesis and tandem asymmetric dihydroxylation–S_N2 cyclization as key steps.