Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes†
Daniela Vuluga,Julien Legros,Benoît Crousse,Danièle Bonnet-Delpon
Green Chemistry Pub Date : 12/09/2008 00:00:00 , DOI:10.1039/B812242C
Abstract

The synthesis of pyrazoles via1,3-dipolar cycloaddition of diazo compounds to alkynes proceeds easily by heating. With α-diazocarbonyl substrates the reactions are conducted under solvent-free conditions affording the pyrazole products in high yields without any work up or purification.

Graphical abstract: Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes