Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides†,10.1039/C5OB01950H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides†

Ling Chen,Lian Yu,Yuan Deng,Yuming Cui,Gaofeng Bian,Jian Cao

Organic & Biomolecular Chemistry Pub Date : 10/21/2015 00:00:00 , DOI:10.1039/C5OB01950H

Abstract

A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.