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Synthetic use of the primary kinetic isotope effect in hydrogen atom transfer: generation of α-aminoalkyl radicals†
Mark E. Wood,Sabine Bissiriou,Christopher Lowe,Andrew M. Norrish,Katell Sénéchal,Kim M. Windeatt,Simon J. Coles,Michael B. Hursthouse
Organic & Biomolecular Chemistry Pub Date : 08/17/2010 00:00:00 , DOI:10.1039/C0OB00205D
Abstract

The extent to which deuterium can act as a protecting group to prevent unwanted 1,5-hydrogen atom transfer to aryl and vinyl radical intermediates was examined in the context of the generation of α-aminoalkyl radicals in a pyrrolidine ring. Intra- and intermolecular radical trapping following hydrogen atom transfer provides an illustration of the use of the primary kinetic isotope effect in directing the outcome of synthetic C–C bond-forming processes.

Graphical abstract: Synthetic use of the primary kinetic isotope effect in hydrogen atom transfer: generation of α-aminoalkyl radicals
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