The first asymmetric synthesis of trialkyl phosphates on the basis of dynamic kinetic resolution in the phosphite method using a chiral source in a catalytic manner†,10.1039/B304163H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

The first asymmetric synthesis of trialkyl phosphates on the basis of dynamic kinetic resolution in the phosphite method using a chiral source in a catalytic manner†

Yoshihiro Hayakawa,Mamoru Hyodo,Kazutaka Kimura,Masanori Kataoka

Chemical Communications Pub Date : 06/13/2003 00:00:00 , DOI:10.1039/B304163H

Abstract

The first asymmetric synthesis of trialkyl phosphates having stereogenic phosphorus atoms on the basis of dynamic kinetic resolution using a chiral source in a catalytic manner; achieved through the stereospecific oxidation of a trialkyl phosphite enantioselectively obtained by the condensation of a racemic unsymmetrically substituted dialkyl phosphorochloridite and an alcohol using a chiral amine as a catalytic promoter.