The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst†,10.1039/C1SC00453K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst†

Taichi Kano,Fumitaka Shirozu,Koichi Tatsumi,Yasushi Kubota,Keiji Maruoka

Chemical Science Pub Date : 08/26/2011 00:00:00 , DOI:10.1039/C1SC00453K

Abstract

A methylenemalonate could be employed as a reactive equivalent of a three carbon Michael acceptor such as acrylate in a direct asymmetric conjugate addition of aldehydes catalyzed by an axially chiral amino diol. The obtained conjugate addition product was readily converted to synthetically useful and important chiral building blocks.