Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate†
Melanie J. Calvert,Susan E. Taylor,Rudolf K. Allemann
Chemical Communications Pub Date : 09/19/2002 00:00:00 , DOI:10.1039/B206517G
Abstract
A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic β-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.
