The first general method for α-trifluoromethylation of carboxylic acids using BrF3†
Aviv Hagooly,Shlomo Rozen
Chemical Communications Pub Date : 02/09/2004 00:00:00 , DOI:10.1039/B315705A
Abstract
2-Carbomethoxy-1,1-bis(methylsulfide)-1-alkenes, easily made from carboxylic acids, CS2 and MeI, were treated with BrF3 producing eventually the desired α-trifluoromethyl carboxylate derivatives – RCH(CF3)COOR′ – in good yields.
