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The p-toluenesulfonic acid catalyzed single pot synthesis of tetracyclic 1,2-dihydroquinolines: a metal free approach†
Anil K. Hajare,Arun R. Jagdale,G. Gautham Shenoy,Neelima Sinha
New Journal of Chemistry Pub Date : 04/19/2016 00:00:00 , DOI:10.1039/C6NJ00928J
Abstract

A simple, convenient and efficient p-toluenesulfonic acid catalyzed tandem reaction of aliphatic ketones with substituted anilines towards the synthesis of polysubstituted 1,2-dihydroquinolines has been developed. The ready availability of the catalyst, operational simplicity, cost effectiveness of the process and excellent regioselectivity mark some of the highlights of this methodology.

Graphical abstract: The p-toluenesulfonic acid catalyzed single pot synthesis of tetracyclic 1,2-dihydroquinolines: a metal free approach
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