Total synthesis of the plant alkaloid racemic microthecaline A: first example of a natural product bearing a tricyclic quinoline-serrulatane scaffold,10.1039/C9RA04675E

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Total synthesis of the plant alkaloid racemic microthecaline A: first example of a natural product bearing a tricyclic quinoline-serrulatane scaffold

Maheshwar Kundarapu,Syed Mohd. Baquer,Anupam Bhattacharya

RSC Advances Pub Date : 07/26/2019 00:00:00 , DOI:10.1039/C9RA04675E

Abstract

The first total synthesis of racemic microthecaline A, a quinoline serrulatane alkaloid, isolated from the Australian desert plant Eremophila microtheca is described. The natural product was synthesized in ten steps, starting from ethyl 4-bromo-6-methoxy-8-methylquinoline-3-carboxylate in 8% overall yield.