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Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides†
Ahalya Behera,Wajid Ali,Manisha Tripathy,Diptimayee Sahoo,Bhisma K. Patel
RSC Advances Pub Date : 08/19/2016 00:00:00 , DOI:10.1039/C6RA16118A
Abstract

A transition metal-free protocol has been developed for the synthesis of α-ketoamides from aryl methyl ketones and alkylphosphoramides in the presence of oxidant, aqueous tert-butyl hydroperoxide (TBHP). A series of aryl methyl ketones having both electron-donating as well as electron-withdrawing groups were successfully employed for the synthesis of their corresponding α-ketoamides using hexamethylphosphoramide and other alkylphosphoramides.

Graphical abstract: Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides
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