Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling†,10.1039/C3QO00021D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling†

Jing Li,Liqun Jin,Chao Liu

Organic Chemistry Frontiers Pub Date : 12/19/2013 00:00:00 , DOI:10.1039/C3QO00021D

Abstract

Transmetalation is the rate-limiting step in Negishi coupling: in a live “Pd-catalyzed Negishi coupling of ArI with Ar′ZnX”, the transmetalation was assigned as the rate-limiting step through kinetic investigation. Quantitative measurements of the transmetalation of ArZnX with [Ar–Pd–X] from this live Pd-catalyzed coupling reaction were obtained and the activation enthalpy is 11.3 kcal mol⁻¹.