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Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)†
Yingkun Shi,Hongqing Xiao,Xiu-Hua Xu,Yangen Huang
Organic & Biomolecular Chemistry Pub Date : 10/22/2018 00:00:00 , DOI:10.1039/C8OB02457J
Abstract

A novel transition metal-free decarboxylative fluoroalkylation of activated alkenes and C–H functionalization cascade process has been developed. This approach provides an efficient way to construct valuable 1,1-dimethyl-2,2,2-trifluoroethyl substituted oxindoles.

Graphical abstract: Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)
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