An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions†,10.1039/B811581H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions†

Xue-Wei Liu,Thanh Nguyen Le,Yunpeng Lu,Yongjun Xiao,Jimei Ma,Xingwei Li

Organic & Biomolecular Chemistry Pub Date : 09/04/2008 00:00:00 , DOI:10.1039/B811581H

Abstract

Chiral pyrrolidine-based phosphinyl oxides were synthesized and their performance as organocatalysts for asymmetric direct aldol reactions was evaluated. High enantioselectivities and diastereoselectivies were achieved for a range of cyclic ketones and aromatic aldehydes.