A simple and benign one-pot protocol for the synthesis of 2-amino selenopyridine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in polyethylene glycol (PEG-400). Under similar reaction conditions, sterically hindered o,o′-disubstituted aromatic aldehydes provide the corresponding functionalized seleno dihydropyridines 5. In this process in total four new bonds (two C–C, one C–N and one C–Se) forms in one pot.