Total synthesis of (+)-swainsonine and (+)-8-epi-swainsonine†,10.1039/C4RA11978A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Total synthesis of (+)-swainsonine and (+)-8-epi-swainsonine†

Milos Trajkovic,Vesna Balanac,Zorana Ferjancic,Radomir N. Saicic

RSC Advances Pub Date : 10/14/2014 00:00:00 , DOI:10.1039/C4RA11978A

Abstract

Enantioselective synthesis of (+)-swainsonine was achieved in 9 steps, with 24% overall yield. The key feature of the synthesis is the tactical combination of reactions: organocatalyzed aldolization/reductive amination, which allows for a rapid construction of highly functionalized heterocyclic systems. In a similar way (+)-8-epi-swainsonine was synthesized (7 steps, 28%).