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Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification†
Freddy Pessel,Isabelle Billault,Marie-Christine Scherrmann
Green Chemistry Pub Date : 07/19/2016 00:00:00 , DOI:10.1039/C6GC01647B
Abstract

An efficient total synthesis of triazole-linked C-glycosyl flavonoids was developed without the use of protective groups in order to promote atom economy, employing alternative solvents, and choosing the least toxic reagents. Aiming to measure the impact of the operation that affects the mass intensity to a greater extent, we envisaged first determining this green metric for the reaction (MIR), the workup (MIW), and the purification (MIP) for each step and then taking advantage of these values to calculate the contributions to the total synthesis.

Graphical abstract: Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification
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