Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)†,10.1039/C9CC06169J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)†

Nobuaki Takahashi,Hideaki Hayashi,Viktors Poznaks,Hideaki Kakeya

Chemical Communications Pub Date : 09/18/2019 00:00:00 , DOI:10.1039/C9CC06169J

Abstract

Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.