Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon†,10.1039/C9OB01629E

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon†

Seohoo Lee,Jaeuk Sim,Hyeju Jo,Mayavan Viji,Lanka Srinu,Kiho Lee,Heesoon Lee,Vishwanath Manjunatha,Jae-Kyung Jung

Organic & Biomolecular Chemistry Pub Date : 08/19/2019 00:00:00 , DOI:10.1039/C9OB01629E

Abstract

Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.