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Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols†
Jai Anand Garg,Subrata Chakraborty,Yehoshoa Ben-David,David Milstein
Chemical Communications Pub Date : 03/10/2016 00:00:00 , DOI:10.1039/C6CC01505K
Abstract

The first example of hydrogenation of amides homogeneously catalyzed by an earth-abundant metal complex is reported. The reaction is catalyzed by iron PNP pincer complexes. A wide range of secondary and tertiary N-substituted 2,2,2-trifluoroacetamides were hydrogenated to form amines and trifluoroethanol.

Graphical abstract: Unprecedented iron-catalyzed selective hydrogenation of activated amides to amines and alcohols
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