[Gd(CyPic3A)(H2O)2]−: a stable, bis(aquated) and high-relaxivity Gd(iii) complex†,10.1039/C3CC44116D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

[Gd(CyPic3A)(H2O)2]−: a stable, bis(aquated) and high-relaxivity Gd(iii) complex†

Eric M. Gale,Nathaniel Kenton,Peter Caravan

Chemical Communications Pub Date : 07/24/2013 00:00:00 , DOI:10.1039/C3CC44116D

Abstract

We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H₂O)₂]⁻ affords an r₁ value of 5.70 mM⁻¹ s⁻¹ at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.