β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1†
Hiroshi Tanaka,Tetsuya Kawai,Yoshiyuki Adachi,Naohito Ohno,Takashi Takahashi
Chemical Communications Pub Date : 10/01/2010 00:00:00 , DOI:10.1039/C0CC03153D
Abstract

In this report, we describe the convergent synthesis of β(1,3) oligosaccharides containing an aminoalkyl group. The branched heptadecasaccharide and linear hexadecasaccharide acted as ligands of dectin-1 whose binding affinity was only 10-fold weaker than that of natural SPG and exhibited dectin-1 agonist activity.

Graphical abstract: β(1,3) Branched heptadeca- and linear hexadeca-saccharides possessing an aminoalkyl group as a strong ligand to dectin-1