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Copper-catalysed amidation of 2-chloro-pyridines†
Lionel Nicolas,Patrick Angibaud,Ian Stansfield,Lieven Meerpoel,Sébastien Reymond,Janine Cossy
RSC Advances Pub Date : 07/19/2013 00:00:00 , DOI:10.1039/C3RA43368D
Abstract

The simple and inexpensive N,N-dimethylcyclohexane-1,2-diamine/CuI catalytic system provides a versatile, easy and efficient access to an array of N-(2-pyridin-2-yl)-amides from 2-chloro-pyridine derivatives.

Graphical abstract: Copper-catalysed amidation of 2-chloro-pyridines
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