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Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement†
Gian Luigi Puleo,Georges Dahm,Gilles Guichard,Stéphane Bellemin-Laponnaz
Chemical Communications Pub Date : 04/18/2011 00:00:00 , DOI:10.1039/C1CC11391G
Abstract

The synthesis of alkyne-substituted N-heterocyclic carbene complexes of Pd(II) and Pt(II) is reported. Catalyzed 1,3-dipolar cycloaddition with azides has been applied as a modular way of functionalisation of group 10 transition metal NHC complexes to generate potentially new metallodrugs.

Graphical abstract: Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement
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