Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans†
Dexuan Xiang,Peng Huang,Kewei Wang,Guangyuan Zhou,Yongjiu Liang
Chemical Communications Pub Date : 10/15/2008 00:00:00 , DOI:10.1039/B815416C
Abstract

A facile and efficient one-pot synthesis of substituted cyclophosphamidic chlorides and their analogues has been developed from readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.

Graphical abstract: Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans