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Efficient and reproducible synthesis of an Fmoc-protected Tn antigen†
Sabrina M. Piazza,Michael R. Reynolds,Jonathan Chiaramonte,Peihan Xu,Fabiola A. Chapa-Villarreal,John F. Trant
New Journal of Chemistry Pub Date : 09/13/2021 00:00:00 , DOI:10.1039/D1NJ01173A
Abstract

This concise total synthesis of the Thomsen-Nouveau (Tn) glycoconjugate was accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-protected serine acceptor. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.

Graphical abstract: Efficient and reproducible synthesis of an Fmoc-protected Tn antigen
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