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Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale†
Steven P. Hanlon,Andrea Camattari,Sandra Abad,Anton Glieder,Matthias Kittelmann,Stephan Lütz,Beat Wirz,Margit Winkler
Chemical Communications Pub Date : 04/25/2012 00:00:00 , DOI:10.1039/C2CC17878H
Abstract

A panel of human flavin monooxygenases were heterologously expressed in E. coli to obtain ready-to-use biocatalysts for the in vitro preparation of human drug metabolites. Moclobemide-N-oxide (65 mg) was the first high-priced metabolite prepared with recombinant hFMO3 on the multi-milligram scale.

Graphical abstract: Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale
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