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Functionalized 2,3-dihydrofurans viapalladium-catalyzed oxyarylation of α-allyl-β-ketoesters†‡§
Sandro Cacchi,Giancarlo Fabrizi,Antonella Goggiamani,Antonia Iazzetti,David Madec,Giovanni Poli,Guillaume Prestat
Organic & Biomolecular Chemistry Pub Date : 10/18/2011 00:00:00 , DOI:10.1039/C1OB06593A
Abstract

The palladium-catalyzed reaction of (hetero)aryl bromides, chlorides, and nonaflates with α-allyl-β-ketoesters provides ready efficient access to functionalized 2,3-dihydrofurans. The reaction tolerates several useful substituents including chloro, fluoro, ether, ketone, ester, cyano, and nitro groups.

Graphical abstract: Functionalized 2,3-dihydrofurans viapalladium-catalyzed oxyarylation of α-allyl-β-ketoesters
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