Highly enantioselective synthesis of syn-aldols of cyclohexanonesvia chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid†
Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99 : 1 syn/anti and 99% ee.
