A one-pot acid-catalyzed tandem reaction has been developed without any metallic reagents or extra oxidants. This reaction involves a C![[double bond, length as m-dash]](http://www.rsc.org/images/entities/char_e001.gif)
C bond cleavage of enones via a “masked” reverse Aldol reaction, and C(sp3)–N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group tolerance.
![Graphical abstract: Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C [[double bond, length as m-dash]] C/C(sp3)–N bond cleavage of enones and primary amines](http://hg.y866.cn/compound/lib/scimg/usr/1/C7RA00780A.jpg)
