In spite of great research efforts on Li–S batteries in aprotic organic electrolytes, there have been very few studies showing the potential application of this system in aqueous electrolyte. Herein, we explore this option and report on a cheaper and safer new aqueous system coupling a well-known cathode material in Li-ion batteries (i.e. LiMn₂O₄) with a dissolved polysulfide anode. In comparison with classical Li–S batteries containing aprotic organic solvents, the aqueous electrolyte offers a stable cycling profile over 100 cycles with faster C-regime.