Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles†
Vincent J. Venditto,Kimberly Allred,Clinton D. Allred,Eric E. Simanek
Chemical Communications Pub Date : 08/11/2009 00:00:00 , DOI:10.1039/B911353C
Abstract
The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.
