An efficient one-pot, Pd(PPh₃)₄ catalyzed, water-promoted method for the synthesis of N-(pyridin-2-ylmethyl) biphenyl-4-sulfonamides was developed under microwave irradiation. This methodology is acid free, has good substrate scope, excellent functional group compatibility, and excellent product yields, and is superior to the existing procedures for the synthesis of biphenyl-4-sulfonamides bearing a pyridin-2-ylmethyl group.